5'-GalNAc C3 -Phosphoramidite
CAS NO. 2437303-51-8

Technical Data of 5'-GalNAc C3 -Phosphoramidite

Advantages of 5'-GalNAc C3-Phosphoramidite

Enhanced Liver Targeting

Utilizes the high affinity of GalNAc for asialoglycoprotein receptors (ASGPR) on hepatocytes, ensuring selective and efficient delivery of oligonucleotide therapeutics to the liver.

Increased Oligonucleotide Stability

Conjugation with 5'-GalNAc C3 enhances the stability of oligonucleotides in biological environments, protecting them from enzymatic degradation.

High Coupling Efficiency

Features exceptional coupling efficiency during solid-phase synthesis, enabling reliable and consistent production of high-purity oligonucleotides.

Biocompatibility and Safety

As a naturally occurring molecule, GalNAc is biocompatible and biodegradable, minimizing immunogenic responses and adverse effects.

Versatility in Nucleic Acid Therapeutics

Suitable for siRNA, antisense oligonucleotides, and gene-editing therapies targeting liver diseases like hypercholesterolemia, hepatitis, and liver fibrosis.

The Applications of 5'-GalNAc C3-Phosphoramidite

RNA Interference (RNAi) Therapies

Application: Used to enhance the delivery of small interfering RNA (siRNA) to hepatocytes, enabling targeted gene silencing.

Antisense Oligonucleotide (ASO) Therapies

Application: Conjugates GalNAc to antisense oligonucleotides, improving stability and specificity for liver-targeted gene modulation.

Gene Editing with CRISPR/Cas9

Supports the delivery of guide RNAs (gRNAs) for CRISPR-based gene editing in liver cells.

Liver-Specific Therapeutic Development

Facilitates the synthesis of modified oligonucleotides conjugated to GalNAc, enhancing their uptake by liver cells for targeted therapeutic applications.

Study of Hepatic Gene Regulation

Used in research to investigate liver-specific gene expression and cellular processes mediated by ASGPR receptors.

mRNA Vaccine Development

Utilized in the development of mRNA vaccines targeting liver cells, increasing their stability and effective delivery.