WUHU HUAREN SCIENCE AND TECHNOLOGY CO., LTD.
GalNAc-NAG37-Phosphoramidite

GalNAc-NAG37-Phosphoramidite
CAS NO. 2199491-27-3

Huaren is capable of supplying the product for lab scale and large scale production.

Products protected by valid patents are only for R&D use,are not offered for sale in coutries where the sale of such products constitutes a patent infringment and its liability is at buyer's risk.

Technical Data of GalNAc-NAG37-Phosphoramidite

Product CodeCAS NO.Product PurityStorage ConditionsMolecular FormulaMolecular Weight
HR-002280012199491-27-3GalNAc-NAG37-Phosphoramidite≥95%(HPLC)-20±5℃C80H127N10O37P1851.9



Advantages of of GalNAc-NAG37-Phosphoramidite

Targeted Liver Delivery

GalNAc-NAG37-Phosphoramidite utilizes N-acetylgalactosamine (GalNAc) to specifically bind to asialoglycoprotein receptors (ASGPR) on hepatocytes. This ensures efficient delivery of therapeutic oligonucleotides, such as siRNA and antisense oligonucleotides, directly to the liver. 


High Coupling Efficiency

With superior coupling efficiency during solid-phase synthesis, GalNAc-NAG37-Phosphoramidite enables the production of high-purity oligonucleotides. 


Exceptional Stability

The phosphoramidite structure of this reagent offers robust chemical stability, ensuring reliable performance during storage and synthesis. 


Biocompatible and Safe

As a naturally occurring and biodegradable molecule, GalNAc is biocompatible, minimizing the risk of immune responses or adverse effects. 


Versatility in Applications

From RNA interference (RNAi) therapies to antisense technologies, GalNAc-NAG37-Phosphoramidite is ideal for developing treatments for diseases such as hypercholesterolemia, hepatitis, and liver fibrosis.


Scalable Production

Huaren Science ensures consistent quality and scalable production, meeting the needs of both small-scale research and industrial manufacturing.


The Applications of GalNAc-NAG37-Phosphoramidite

RNA Interference (RNAi) Therapies

Facilitates the delivery of small interfering RNAs (siRNAs) to hepatocytes, enabling precise gene silencing for therapeutic purposes.


Antisense Oligonucleotide (ASO) Therapies

Application: Enhances the stability and delivery of ASOs, improving their efficacy in modulating gene expression.


Gene Editing with CRISPR-Cas9

Supports the targeted delivery of guide RNAs (gRNAs) for gene editing applications in liver cells.


Therapeutic Oligonucleotide Development

Used in the synthesis of modified oligonucleotides with GalNAc ligands for enhanced biodistribution and reduced off-target effects.


Research in Liver Biology

Enables precise studies on liver-specific gene expression, cellular uptake, and receptor-ligand interactions.


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