5-Me-CMP
CAS NO. 3590-36-1

Technical Data of 5-Me-CMP

Advantages of 5-Me-CMP

Epigenetic Modulation

The addition of a methyl group at the 5-position of the cytosine ring mimics natural DNA methylation, playing a crucial role in epigenetic regulation.

Enhances Stability of Nucleic Acids

5-Me-CMP contributes to the enhanced stability of oligonucleotides by modifying the nucleic acid backbone.

High Incorporation Efficiency

During solid-phase oligonucleotide synthesis, 5-Me-CMP can be efficiently incorporated into both DNA and RNA sequences.

Applications in DNA Methylation Studies

5-Me-CMP serves as a valuable tool for studying DNA methylation patterns, which play a critical role in gene expression, aging, and various diseases.

Role in Gene Regulation

Incorporating 5-Me-CMP into nucleic acids can mimic methylation-induced gene silencing, which is important for gene regulation and therapeutic strategies targeting gene expression.

Versatility in Research and Therapeutics

5-Me-CMP is widely used in both basic research and therapeutic applications, including gene therapy, nucleic acid-based vaccines, and epigenetic drug development.

The Applications of 5-Me-CMP

Epigenetic Research and DNA Methylation Studies

5-Me-CMP is widely used to study the role of DNA methylation in gene regulation. By incorporating 5-Me-CMP into oligonucleotides, researchers can investigate the effects of methylation on gene expression and chromatin structure.

Gene Expression Regulation

 The methyl group added at the 5-position of cytosine mimics the DNA methylation modification that naturally silences genes, offering a tool for regulating gene expression in research and therapeutic contexts.

DNA-Based Therapeutics and Gene Therapy

5-Me-CMP is used in the development of DNA-based therapies, particularly in gene silencing strategies such as antisense oligonucleotides (ASOs) and RNA interference (RNAi).

Oligonucleotide Synthesis for Therapeutic Applications

5-Me-CMP is incorporated into synthetic DNA or RNA oligonucleotides to enhance their stability and resistance to enzymatic degradation, making them more effective for therapeutic applications.

Studying Methylation-Specific DNA-Protein Interactions

5-Me-CMP is used to probe the interactions between DNA and methylation-sensitive proteins, helping to elucidate the mechanisms of transcriptional regulation.

Development of Methylation-Targeted Drugs

The use of 5-Me-CMP is instrumental in developing small molecules or drugs that target DNA methylation pathways, offering new approaches for cancer treatment, gene regulation, and disease prevention.